Population
Nephrectomized and paired sham-nephrectomized control rats under pentobarbital anesthesia (n=12 pairs)
Comparison
Nephrectomy with renin and angiotensin I infusions vs Paired sham-nephrectomized control rats
Design
Preclinical
Follow-up
22 hours
Authors
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Halved renin clearance after nephrectomy prolongs pressor responses in rats; extends mechanistic models but leaves open human translation.
The prolonged pressor response to renin after nephrectomy in rats is driven by both altered angiotensin I dose-response and decreased plasma renin clearance.
G. W. Boyd (1979) studied this question.
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