The half-life of circulating endogenous renin in rats is approximately 10 minutes following bilateral nephrectomy.
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Rat renin half-life data warrant caution in clinical translation; leaves open confirmatory human studies.
SUMMARY 1. Plasma renin concentration (PRC) was measured in eight male rats at intervals during a 6 h period after bilateral nephrectomy. 2. PRC fell rapidly, reaching 51% of the mean control level by 10 min, 29% by 30 min, and 2% by 4 h. 3. Under the conditions of the experiment, the half-life of circulating endogenous renin in the rat was about 10 min.
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Oates et al. (1974) studied this question.
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