What question did this study set out to answer?

To determine the plasma kinetics and physiological source of inactive renin following complete kidney removal in rats.

September 1, 1984Hypertension

Evidence for an extrarenal source of inactive renin in rats.

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Suggests extrarenal inactive renin sources in rats; leaves open their identity and relevance to human hypertension.

To determine the plasma kinetics and physiological source of inactive renin following complete kidney removal in rats.
Monitored active and inactive renin levels in rat plasma at sequential intervals following bilateral nephrectomy.
Characterized renin forms using Sephacryl S-200 gel filtration, Cibacron blue chromatography, and pH optimum assays.
Performed surgical ablation of multiple candidate organs—including salivary glands, uterus, spleen, pancreas, digestive tract, adrenals, and pituitary—to test for the secretory source.
Active renin rapidly cleared from plasma post-nephrectomy with a half-life of approximately 15 minutes.
Inactive renin increased from a baseline of 20.96 ± 1.63 ng/ml/hr to a peak of 193 ± 62 ng/ml/hr at 20 hours after bilateral nephrectomy.
Ablation of the salivary glands, uterus, spleen, pancreas, stomach, intestines, adrenal glands, or pituitary failed to prevent the post-nephrectomy increase in inactive renin.

Doi et al. (1984) studied this question.

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