Population
Rat plasma from conscious rats and 30-h nephrectomized rats
Comparison
Acute in vivo renin stimulation, diabutal… vs Normal rat plasma / control conditions
Design
Preclinical
Authors
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No immediate clinical implications from rat plasma factor; leaves open translational relevance to human prorenin activation.
This preclinical study confirms the existence of an endogenous plasma factor in rats capable of converting inactive prorenin to active renin.
Barrett et al. (1981) studied this question.
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