Key result
Exposure to cold, acid, or trypsin did not activate renin secreted from isolated perfused rat kidneys, suggesting that rat kidneys do not secrete inactive renin.
Population
Isolated perfused rat kidney and binephrectomized rat plasma
Comparison
Exposure to cold, dialysis to pH 3.3, trypsin… vs Dialysis to pH 6.5 or untreated perfusate
Design
Preclinical
Authors
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Rat kidneys do not secrete inactive renin; leaves open species differences and plasma inactivation artifacts in human assays.
The study demonstrates that rat kidneys do not secrete inactive renin and highlights that renin inactivation by plasma at neutral pH can confound measurements of acid-activatable renin.
Nakane et al. (1979) studied this question. Acid, trypsin, and cold treatment was evaluated on Renin concentration and activity. Exposure to cold, acid, or trypsin did not activate renin secreted from isolated perfused rat kidneys, suggesting that rat kidneys do not secrete inactive renin.
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