Key result
In vivo stimulation or suppression of active plasma renin in rats suggested independent regulation of active and inactive renin, with similar renins activated both in vivo and in vitro.
Population
Rats (plasma samples)
Comparison
In vivo stimulation or suppression of active… vs Baseline levels before stimulation or suppression
Design
Preclinical
Authors
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May support independent renin regulation in rats; hypothesis-generating and leaves open human translation.
This preclinical study suggests that active and inactive renin may be regulated independently in vivo in rats, and that physiological activation involves enzymatic cleavage similar to in vitro trypsin activation.
Barrett et al. (1982) studied this question. In vivo stimulation or suppression of active plasma renin vs. Baseline was evaluated on Levels of active, inactive, and total renin. In vivo stimulation or suppression of active plasma renin in rats suggested independent regulation of active and inactive renin, with similar renins activated both in vivo and in vitro.
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