Key result
Trypsin activation of inactive renin in rat plasma has a pH optimum of 6.2, and on average, 40% of total circulating renin can be activated by trypsin.
Population
Rat plasma
Design
Preclinical
Authors
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Optimizes trypsin activation conditions in rat plasma; extends experimental renin methods while leaving human translation open.
This basic science study defines the optimal experimental conditions (pH, concentration, time) for trypsin activation of inactive renin in rat plasma.
Glorioso et al. (1982) studied this question. Trypsin was evaluated on Activation of inactive renin. Trypsin activation of inactive renin in rat plasma has a pH optimum of 6.2, and on average, 40% of total circulating renin can be activated by trypsin.
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