Key result
Trypsinization of plasma from healthy volunteers increased plasma renin activity 3-fold from 2.8 to 8.3 ng/ml.h (P<0.001), supporting the existence of an inactive renin precursor.
Population
3 plasma pools and plasmas from 26 healthy volunteers ambulatory for 3 h
Comparison
Trypsinization vs Baseline plasma (untreated)
Design
Preclinical
Authors
Loading...
Indicates inactive renin in human plasma; leaves open its physiological role and clinical relevance.
Effect estimate: 3-fold increase
Absolute Event Rate: 8.3% vs 2.8%
p-value: p=<0.001
Tryptic activation increases plasma renin activity, supporting the existence of an inactive precursor form of renin in human plasma.
Noth et al. (1980) studied Healthy (n=26). Trypsin vs. Baseline was evaluated on Plasma renin activity (PRA) (3-fold increase, p=<0.001). Trypsinization of plasma from healthy volunteers increased plasma renin activity 3-fold from 2.8 to 8.3 ng/ml.h (P<0.001), supporting the existence of an inactive renin precursor.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: