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March 1, 1986The Journal of Clinical Endocrinology & Metabolism

Activation of Plasma and Amniotic Prorenin by Metalloprotease and Trypsin*

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Population

Plasma samples from 17 normotensive and 58 hypertensive subjects, and human amniotic fluid

Comparison

Thermolysin (metalloprotease) vs Trypsin

Design

Preclinical

Authors

YTYasuharu TakadaMeijo HospitalSBStephen BrownBallarat Health ServicesEEErvin G. ErdösGeneral / Preventive / Lipids

Discussion

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Implication

Thermolysin models prorenin activation by metalloproteases; hypothesis-generating in animal hypertension studies, should not change practice.

Structured PICO

P
Population
Plasma samples from 17 normotensive and 58 hypertensive subjects, and human amniotic fluid
I
Intervention
Thermolysin (metalloprotease)
C
Comparator
Trypsin
O
Outcome
Activation of prorenin to active reninsurrogate

Thermolysin is a potent activator of human prorenin, demonstrating that metalloproteases can serve as models for prorenin activation.

Cite This Study

Takada et al. (1986) studied this question.

synapsesocial.com/papers/6a70f1cd87f921057127fcc7https://doi.org/10.1210/jcem-62-3-569
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An Inactive, Prorenin-like Substance in Human Kidney and Plasma1980 · 40 citations
  2. 2Potential effects of renin activation on the regulation of renin production1984 · 29 citations
  3. 3Biochemical Properties of Big Renin Extracted from Human Plasma1975 · 88 citations
  4. 4Human kidney "enkephalinase", a neutral metalloendopeptidase that cleaves active peptides1983 · 288 citations
  5. 5Increased Renin Activity after Cold Storage of Human Plasma1973 · 125 citations