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July 1, 1980Endocrinology

Effect of Trypsin or Acid Treatment on Dog Plasma Renin Activity Measurements*

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Population

Dog plasma (including plasma from anephric dogs)

Design

Preclinical

Authors

JGJohn F. GallagherUniversity College DublinJLJohn H. LaraghGeneral CardiologySASteven A. AtlasGeneral / Preventive / Lipids

Discussion

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Implication

Species differences in canine plasma advise caution extrapolating to humans; leaves open optimal renin assay methods across species.

Structured PICO

P
Population
Dog plasma (including plasma from anephric dogs)
I
Intervention
Acid treatment (pH 3.3), trypsin treatment (>1000 μg/ml), or cryoactivation (incubation for 4 days at -4 C)
O
Outcome
Plasma renin activity (rate of angiotensin I formation)surrogate

In dog plasma, acid or trypsin treatment increases angiotensin I generation by altering renin substrate rather than activating inactive renin, indicating a difference from human plasma.

Cite This Study

Gallagher et al. (1980) studied this question.

synapsesocial.com/papers/6a83c545f4298de60b3c2be3https://doi.org/10.1210/endo-107-1-147
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Studies on Renin1972 · 12 citations
  2. 2Evidence Favoring the Existence of Two High Molecular Weight Precursor Forms of Dog Kidney Renin*1979 · 7 citations
  3. 3"Prorenin" in human plasma?1975 · 82 citations
  4. 4Increased Renin Activity after Cold Storage of Human Plasma1973 · 125 citations
  5. 5Occurrence of Big Renin in Human Plasma, Amniotic Fluid and Kidney Extracts1975 · 138 citations