Why the study?
Does nephrectomy alter the plasma levels and distribution of renin-angiotensin system components in humans?
Population
Humans undergoing nephrectomy
Comparison
Nephrectomy (monitoring post-nephrectomy) vs Pre-nephrectomy levels
Design
Cohort
Follow-up
1-2 days post-nephrectomy
Authors
Loading...
Post-nephrectomy RAS persistence indicates extrarenal prorenin sources; hypothesis-generating for tissue effects in anephric patients.
Does nephrectomy alter the plasma levels and distribution of renin-angiotensin system components in humans?
Renal renin and prorenin enter tissue sites in humans, with renal renin being the main determinant of plasma angiotensins, while prorenin also originates from extrarenal sites.
Krop et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: