Key result
A renin-like enzyme indistinguishable from human renal renin was found in the plasma of 4 of 6 anephric subjects (all women), with uterine tissue identified as a likely extrarenal source.
Population
6 anephric subjects (5 women and 1 man), 1 to 8 months post nephrectomy
Design
Case_series
Follow-up
1 to 8 months post nephrectomy
Authors
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No immediate clinical implications for anephric patients; leaves open the physiological role of uterine renin.
Observational (n=6)
This study provides the first evidence in humans of an extrarenal site of renin synthesis, identifying the uterus as a likely source.
Capelli et al. (1968) conducted an observational in Anephric subjects (n=6). Anephric state (post nephrectomy) was evaluated on Plasma renin activity and characterization of renin-like enzyme. A renin-like enzyme indistinguishable from human renal renin was found in the plasma of 4 of 6 anephric subjects (all women), with uterine tissue identified as a likely extrarenal source.
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