Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1994CirculationOpen Access

Renin is not synthesized by cardiac and extrarenal vascular tissues. A review of experimental evidence.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Physiological and molecular biological evidence challenging claims that renin is synthesized by cardiac and vascular tissues needed comprehensive review.

Design

Comprehensive review of experimental evidence

Authors

NLNicola von LutterottiDCDaniel F. CatanzaroJSJean E. Sealey

Discussion

Loading...

Member takes

Overview

Reaffirms plasma renin measurements' clinical utility; leaves open extrarenal contributions in disease pending rigorous validation.

Key Points

  • This review aims to clarify the sources of renin production, emphasizing the kidneys' exclusivity in synthesizing biologically active renin.
  • Comprehensive analysis of physiological and molecular biological studies on renin synthesis.
  • Examination of renin detection methods and potential pitfalls in prior research findings.
  • Critical evaluation of conditions like binephrectomy and mRNA detection in cardiac and vascular tissues.
  • All evidence supports that renin synthesis originates solely from the kidneys, with no active renin produced in cardiac or vascular tissues.
  • Detection of renin mRNA in non-renal tissues can be attributed to methodological issues, such as insufficient kidney removal prior to testing.
  • Plasma renin levels are exclusively regulated by renal mechanisms, influencing cardiovascular health and drug efficacy.

Cite This Study

Lutterotti et al. (1994) studied this question.

synapsesocial.com/papers/6a227e77ffccceb004b72ef8https://doi.org/10.1161/01.cir.89.1.458
View Full Paper
Ask AI
Bookmark
Share