Key result
Nephrectomy or ureteral ligation in rats increases vascular response to intravenous angiotensin, coinciding with a rise in plasma potassium and a fall in the sodium-to-potassium ratio.
Nephrectomy or ureteral ligation in rats increases vascular sensitivity to angiotensin, potentially mediated by plasma ionic shifts.
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Hypothesis-generating in rat renal failure models; leaves open whether ionic shifts modulate angiotensin sensitivity in humans.
An increased response to iv angiotensin occurs in rats from 10 to 20 hr after ureteral ligations or nephrectomy. During this time there is also a rise in plasma K and a marked fall in Na/K ratio. It is suggested that the vascular bed is more sensitive to the action of angiotensin when the ionic shift has taken place in the plasma.
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Stouder et al. (1972) studied this question. Nephrectomy or ureteral ligation in rats increases vascular response to intravenous angiotensin, coinciding with a rise in plasma potassium and a fall in the sodium-to-potassium ratio.
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