Why the study?
Does bilateral nephrectomy alter vascular reactivity to Angiotensin II and noradrenaline in rats?
Population
Anaesthetized rats bilaterally nephrectomized for 24-48 h
Comparison
Angiotensin II (AT II) and noradrenaline (NA) vs Control animals which underwent the same…
Design
Preclinical
Follow-up
24-48 hours
Authors
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Enhanced Ang II pressor response post-nephrectomy is not explained by vascular supersensitivity; leaves open alternative mechanisms in animal models.
Does bilateral nephrectomy alter vascular reactivity to Angiotensin II and noradrenaline in rats?
The increased pressor effect of Angiotensin II in nephrectomized rats cannot be explained by increased sensitivity of large vessels or the femoral vascular bed.
Couture et al. (1978) studied this question.
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