Why the study?
Does depletion of endogenous renin contribute to enhanced pressor responsiveness following bilateral nephrectomy in dogs?
Population
Nephrectomized dogs
Comparison
Crude kidney extracts, continuous infusion of… vs Liver extracts alone or continuous infusion of…
Design
Preclinical
Follow-up
48 hours (for infusion)
Authors
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Provides mechanistic insight from canine models; leaves open translation to human post-nephrectomy hypertension.
Does depletion of endogenous renin contribute to enhanced pressor responsiveness following bilateral nephrectomy in dogs?
Depletion of endogenous renin contributes to the enhanced cardiovascular pressor responsiveness observed after bilateral nephrectomy in dogs.
Buñag et al. (1968) studied this question.
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