Key result
In outpatients with essential hypertension, cardiac index correlated negatively and total peripheral resistance correlated positively with age, while plasma volume was significantly increased in those over 60 years compared to normal volunteers.
Cross-Sectional (n=145)
Effect estimate: r=-0.379 for cardiac index; r=0.407 for total peripheral resistance
p-value: p=<0.01
Hemodynamic profiles and neurohormonal activity in essential hypertension vary significantly with age and salt intake.
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Age-related hemodynamic shifts in hypertension may guide evaluation; leaves open outcome prediction and therapeutic targeting.
Kasahara et al. (1985) conducted a cross-sectional in Essential hypertension (n=145). Essential hypertension and advancing age vs. Normotensive controls was evaluated on Correlation of cardiac index and total peripheral resistance with age (r=-0.379 for cardiac index; r=0.407 for total peripheral resistance, p=<0.01). In outpatients with essential hypertension, cardiac index correlated negatively and total peripheral resistance correlated positively with age, while plasma volume was significantly increased in those over 60 years compared to normal volunteers.
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