Key result
The concentration of active renin in arterial plasma decreased from 4.4 +/- 1.1 ng/ml in 3-5-day-old piglets to 0.7 +/- 0.1 ng/ml in 42-53-day-old piglets, while the rate of release was unchanged.
The qualitative control of renin release is similar across various stages of development in piglets, suggesting differences in plasma renin concentration depend on factors other than kidney release.
Stable renin release during piglet maturation; leaves open whether clearance drives age-related plasma declines in human neonates.
The release of both active and acid-activatable (inactive), renin was determined in piglets ranging in age from 3 to 53 days. The concentration of active renin in arterial plasma during control periods decreased from 4.4 +/- 1.1 ng/ml in 3--5-day-old animals to 0.7 +/- 0.1 ng/ml in 42-53-day-old animals, while the rate of release of active renin was unchanged (11.8 +/- 5.1 ng/min and 7.5 +/- 3.4 ng/min, respectively). Both isoproterenol and furosemide stimulated release of renin in all age animals while propranolol supressed renin release. The data indicate that the qualitative control of renin release is similar in animals of various ages and stages of development. However, the differences in the concentration of renin in plasma of newborn and more mature animals may depend on factors other than release of renin by the kidney. Newborn animals release both active and inactive renin from the kidney.
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Bailie et al. (2019) studied this question. Developmental age was evaluated on Concentration and rate of release of active and inactive renin. The concentration of active renin in arterial plasma decreased from 4.4 +/- 1.1 ng/ml in 3-5-day-old piglets to 0.7 +/- 0.1 ng/ml in 42-53-day-old piglets, while the rate of release was unchanged.
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