Why the study?
Verapamil has been studied extensively in adult animals, but there were limited data regarding its electrophysiologic and hemodynamic effects in young animals.
Does intravenous verapamil have different electrophysiologic and hemodynamic effects in puppies compared to adult dogs?
Comparison
Puppies vs adult dogs receiving intravenous verapamil (50, 100, 200, and 400 microgram/kg)
Design
Comparative animal physiologic study
Authors
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Verapamil effects differ by age and anesthesia in dogs; leaves open age-specific dosing implications for pediatric arrhythmia management.
Does intravenous verapamil have different electrophysiologic and hemodynamic effects in puppies compared to adult dogs?
Verapamil produces comparable electrophysiologic effects in puppies and adult dogs, though anesthesia significantly amplifies its impact on heart rate and refractoriness.
Gibson et al. (2019) studied this question.
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