The effect of verapamil on mechanical performance of acutely ischemic and reperfused myocardium in the conscious dog.
Why the study?
Does verapamil improve the mechanical performance of acutely ischemic and reperfused myocardium in a conscious dog model?
Population
12 intact conscious dogs with myocardial ischemia produced by inflating a balloon cuff implanted on the left…
Comparison
Continuous infusion of verapamil beginning prior… vs Normal saline infusion
Design
Preclinical
Follow-up
Acute (during and after coronary occlusion)
Authors
Discussion
Loading...
Member takes
Implication
Verapamil may preserve ischemic myocardial function via calcium antagonism in dogs; leaves open translation to human acute ischemia.
Structured PICO
Does verapamil improve the mechanical performance of acutely ischemic and reperfused myocardium in a conscious dog model?
P
Population
12 intact conscious dogs with myocardial ischemia produced by inflating a balloon cuff implanted on the left anterior descending coronary artery
I
Intervention
Continuous infusion of verapamil (10 microgram/kg per min) beginning prior to coronary occlusion
C
Comparator
Normal saline infusion
O
Outcome
Systolic ejection shortening (SES) measured from subendocardial ultrasonic crystals in the central ischemic zone, border zone, and nonischemic control zonesurrogate
Verapamil pretreatment exerts beneficial effects on the mechanical performance of ischemic myocardium in a conscious dog model, likely due to its calcium-antagonistic properties rather than hemodynamic changes.
Cite This Study
Sherman et al. (1981) studied this question.