What does this research mean for the field?

Pre-treatment with the calcium antagonist verapamil significantly reduces myocardial necrosis following temporary coronary artery occlusion and reperfusion in dogs, with higher doses providing greater protection. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study examines the role of verapamil in reducing myocardial necrosis following temporary coronary artery occlusion.

April 1, 1977CirculationOpen Access

Effect of the calcium antagonist verapamil on necrosis following temporary coronary artery occlusion in dogs.

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Why the study?

Does verapamil reduce myocardial necrosis in dogs subjected to temporary coronary artery occlusion?

Population

Dogs subjected to 40 min of left circumflex coronary artery occlusion followed by 2-4 days of reperfusion

Comparison

Verapamil intravenously vs Untreated dogs

Design

Preclinical

Follow-up

2-4 days

Authors

KRK A ReimerCross-Cutting Cardiology JLJ. E. LoweUniversity of North Carolina at Chapel Hill RJRobert B. JenningsUniversité Claude Bernard Lyon 1

Discussion

Member takes

Implication

Hypothesis-generating for calcium channel blockade in ischemia; should not change clinical practice pending human data.

Key Points

This study examines the role of verapamil in reducing myocardial necrosis following temporary coronary artery occlusion.
Three groups of dogs subjected to temporary left circumflex coronary artery occlusion: untreated, low-dose (0.8 mg/kg) verapamil, and higher doses of verapamil.
Verapamil administered intravenously starting 10 min before occlusion.
Quantification of necrosis performed histologically on transmural slices of posterior papillary muscle.
Lower dose verapamil resulted in 14% necrosis compared to 35% in untreated dogs.
Higher doses were more effective in limiting necrosis despite causing hypotension and heart block.

Structured PICO

Does verapamil reduce myocardial necrosis in dogs subjected to temporary coronary artery occlusion?

Population

Dogs subjected to 40 min of left circumflex coronary artery occlusion followed by 2-4 days of reperfusion

Intervention

Verapamil intravenously (0.8 mg/kg over 30 min beginning 10 min prior to occlusion, or higher dose until complicated by hypotension or conduction abnormalities)

Comparator

Untreated dogs

Outcome

Myocardial necrosis quantitated histologically in transmural slices through the posterior papillary musclesurrogate

Pre-treatment with intravenous verapamil significantly limits myocardial necrosis following temporary coronary artery occlusion and reperfusion in a canine model.

Cite This Study

Reimer et al. (1977) studied this question.

synapsesocial.com/papers/6a1bf0421567d2fc4d5f4aa1 https://doi.org/10.1161/01.cir.55.4.581

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Effect of the calcium antagonist verapamil on necrosis following temporary coronary artery occlusion in dogs.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of the calcium antagonist verapamil on necrosis following temporary coronary artery occlusion in dogs.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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