Key result
Verapamil infusion substantially reduced the extracellular K+ rise produced by myocardial ischaemia in both the central and marginal zones in dogs.
Why the study?
Does verapamil infusion reduce the extracellular K+ rise during myocardial ischemia in dogs?
Population
26 open chest mongrel dogs with myocardial ischemia produced by intermittent occlusion of the LAD artery or…
Comparison
Verapamil infusion vs Controlled conditions (ischemia without verapamil)
Design
Preclinical
Authors
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Hypothesis-generating for verapamil in ischemic K+ dynamics; human trials needed before any clinical consideration.
Does verapamil infusion reduce the extracellular K+ rise during myocardial ischemia in dogs?
Verapamil reduces the extracellular potassium rise during myocardial ischemia in a canine model, potentially via coronary dilation or reduced cellular K+ conductance.
López et al. (1985) studied myocardial ischaemia (n=26). verapamil vs. controlled conditions was evaluated on extracellular K+ rise ([K+]o). Verapamil infusion substantially reduced the extracellular K+ rise produced by myocardial ischaemia in both the central and marginal zones in dogs.
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