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April 1, 1986CirculationOpen Access

Effects of verapamil on ischemia-induced changes in extracellular K+, pH, and local activation in the pig.

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Why the study?

Does verapamil reduce ischemia-induced changes in extracellular K+, pH, and local activation in a swine model of acute myocardial ischemia?

Population

Open-chest, anesthetized swine

Comparison

Verapamil administered during a series of 10 min… vs Control occlusions

Design

Preclinical

Follow-up

10 minutes (duration of occlusions)

Authors

WFWilliam F. FleetUniversity of North Carolina at Chapel HillTJTimothy A. JohnsonPurdue University West LafayetteCGC GraebnerUniversitätsklinikum Erlangen

Discussion

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Implication

Hypothesis-generating for verapamil in acute ischemia; clinical translation from swine model remains untested.

Structured PICO

Does verapamil reduce ischemia-induced changes in extracellular K+, pH, and local activation in a swine model of acute myocardial ischemia?

P
Population
Open-chest, anesthetized swine
I
Intervention
Verapamil (0.2 mg/kg) administered during a series of 10 min occlusions of the left anterior descending coronary artery
C
Comparator
Control occlusions
O
Outcome
Ischemia-induced changes in left ventricular local activation, extracellular K+ ([K+]e), and extracellular pH (pHe)surrogate

In a swine model of acute myocardial ischemia, verapamil attenuates ischemia-induced increases in extracellular potassium, acidosis, and local activation delay.

Cite This Study

Fleet et al. (1986) studied this question.

synapsesocial.com/papers/6a731d124499ffee882b3002https://doi.org/10.1161/01.cir.73.4.837
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enhancement of the vulnerability of the ventricle to fibrillation (VF) by regional hyperkalemia1973 · 20 citations
  2. 2EFFECTS OF CALCIUM ANTAGONISTS ON THE ALTERNATION OF THE ST‐T COMPLEX AND ASSOCIATED CONDUCTION ABNORMALITIES DURING CORONARY OCCLUSION IN DOGS1981 · 15 citations