Key result
Infusion of ANG II increased muscle sympathetic nerve activity in patients with primary aldosteronism, whereas it decreased in normotensive controls.
Why the study?
Does infusion of ANG II increase muscle sympathetic nerve activity in patients with primary aldosteronism compared to normotensive controls?
Population
9 patients with primary aldosteronism (PA) and 16 age-matched normotensive controls (NC)
Comparison
Infusion of a high physiological dose of ANG II… vs Age-matched normotensive controls receiving the…
Design
Case-control
Authors
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May explain suppressed sympathetic activity via low angiotensin II in primary aldosteronism; leaves open effects on outcomes or therapy.
Does infusion of ANG II increase muscle sympathetic nerve activity in patients with primary aldosteronism compared to normotensive controls?
Suppressed sympathetic nerve activity in primary aldosteronism is partly driven by low endogenous angiotensin II levels, as exogenous ANG II infusion paradoxically increases sympathetic activity in these patients.
Matsukawa et al. (2008) studied Primary aldosteronism (n=25). ANG II infusion vs. Normotensive controls was evaluated on Muscle sympathetic nerve activity (MSNA). Infusion of ANG II increased muscle sympathetic nerve activity in patients with primary aldosteronism, whereas it decreased in normotensive controls.
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