Why the study?
Does angiotensin II or ACE inhibition alter reflex sympathetic inhibition in humans?
Population
48 subjects: 28 patients with essential hypertension with elevated plasma renin activity and 20 normotensive…
Comparison
Acute oral captopril or chronic oral imidapril… vs Placebo in hypertensive patients; vehicle in…
Design
Other
Follow-up
Up to 12 weeks
Authors
Loading...
Supports ACE inhibitor sympathoinhibition via reflex changes in humans; extends animal data yet leaves open clinical translation.
Does angiotensin II or ACE inhibition alter reflex sympathetic inhibition in humans?
Angiotensin II blunts and ACE inhibitors augment reflex sympathetic inhibition in humans, providing a physiological mechanism for the sympathoinhibitory effects of ACE inhibitors in hypertension.
Miyajima et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: