Key result
Intracoronary Angiotensin II markedly enhanced sympathetic coronary vasoconstriction during cold pressor test and diving compared to saline, causing a marked increase in coronary vascular resistance.
Why the study?
Does intracoronary Angiotensin II potentiate coronary sympathetic vasoconstriction in normotensive patients with mild coronary artery lesions?
Population
12 normotensive patients with angiographic evidence of mild left coronary artery lesions
Comparison
15-minute left intracoronary infusion of… vs 15-minute left intracoronary infusion of saline…
Authors
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Supports ACE inhibitor rationale in CAD via sympathetic modulation; leaves open translation to clinical outcomes.
Does intracoronary Angiotensin II potentiate coronary sympathetic vasoconstriction in normotensive patients with mild coronary artery lesions?
Intracoronary Angiotensin II markedly enhances sympathetic coronary vasoconstriction, providing a mechanistic explanation for the anti-ischemic benefits of ACE inhibition in patients with coronary artery disease.
Saino et al. (1997) studied Mild left coronary artery lesions (n=12). Angiotensin II vs. Saline was evaluated on Coronary vascular resistance and coronary sinus blood flow during cold pressor test and diving. Intracoronary Angiotensin II markedly enhanced sympathetic coronary vasoconstriction during cold pressor test and diving compared to saline, causing a marked increase in coronary vascular resistance.
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