Why the study?
Does lisinopril alter sympathetic nerve traffic and baroreflex control in untreated mild to moderate essential hypertensive patients?
Population
18 untreated mild to moderate essential hypertensive patients, mean age 48.5+/-1.9 years
Comparison
Lisinopril 10 mg/day orally for 2 months vs 2 month observation period without drug…
Design
Cohort
Follow-up
2 months
Authors
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Lisinopril-associated BP reduction occurs without sympathetic changes in essential hypertension; hypothesis-generating and requires RCT confirmation.
Does lisinopril alter sympathetic nerve traffic and baroreflex control in untreated mild to moderate essential hypertensive patients?
Chronic ACE inhibition with lisinopril lowers blood pressure without affecting sympathetic nerve traffic or baroreflex control in essential hypertension.
Grassı et al. (1998) studied this question.
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