Key result
Pressor infusions of angiotensin II raised mean arterial pressure (p<0.001) but did not affect plasma norepinephrine or norepinephrine spillover in healthy volunteers.
Why the study?
Does a pressor infusion of angiotensin II stimulate the sympathetic nervous system as reflected by norepinephrine spillover in healthy volunteers?
Population
n=6 healthy volunteers
Comparison
Angiotensin II infused at 5 ng/kg/min for 30… vs Vehicle and phenylephrine infusions as controls…
Follow-up
30-minute infusions plus 30 minutes of tilt testing
Authors
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Ang II pressor effects occur without sympathetic activation in healthy volunteers; challenges direct sympathoexcitation and leaves open disease-state relevance.
Does a pressor infusion of angiotensin II stimulate the sympathetic nervous system as reflected by norepinephrine spillover in healthy volunteers?
Pressor infusions of angiotensin II raise mean arterial pressure without stimulating norepinephrine spillover or lowering heart rate in healthy humans.
Goldsmith et al. (1991) studied Healthy (n=6). Angiotensin II (AII) vs. Vehicle and phenylephrine was evaluated on Norepinephrine (NE) spillover. Pressor infusions of angiotensin II raised mean arterial pressure (p<0.001) but did not affect plasma norepinephrine or norepinephrine spillover in healthy volunteers.
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