What question did this study set out to answer?

To investigate whether ACE inhibitor therapy can prevent volume-overload cardiac hypertrophy in dogs with mitral regurgitation.

August 1, 1997AJP Heart and Circulatory Physiology

Volume-overload cardiac hypertrophy is unaffected by ACE inhibitor treatment in dogs

Q: What does this research mean for the field?

ACE inhibitor treatment does not prevent volume-overload cardiac hypertrophy or collagen matrix dissolution in chronic mitral regurgitation, potentially due to compensatory upregulation of the AT1 receptor. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Why the study?

Does ramipril prevent volume-overload hypertrophy in dogs with chronic mitral regurgitation?

Population

18 adult mongrel dogs with induced chronic mitral regurgitation (MR)

Comparison

Ramipril 10 mg orally twice daily for 4 months vs No ramipril for 4 months after induction of MR

Design

Preclinical

Follow-up

4 months

Authors

LDL. J. Dell'ItaliaDokkyo University EBEduardo BalcellsSouth Shore Hospital QMQing Cheng MengHenan Normal University

Discussion

Member takes

Implication

Ramipril does not prevent hypertrophy in canine volume-overload MR; leaves open ACE inhibitor utility in human chronic mitral regurgitation.

Key Points

To investigate whether ACE inhibitor therapy can prevent volume-overload cardiac hypertrophy in dogs with mitral regurgitation.
Compared 7 dogs treated with ramipril and 11 untreated dogs for 4 months after induction of mitral regurgitation.
Cine-magnetic resonance imaging was used to assess left ventricular mass and myocyte cell length.
Measured LV ACE, chymase activities, and angiotensin II levels.
LV mass increased significantly in both treated (80 to 108 g, P < 0.01) and untreated dogs (92 to 112 g, P < 0.001).
LV angiotensin II levels reduced in treated dogs (28 pg/g, P < 0.05) compared to untreated (72 pg/g).
AT1-receptor mRNA levels increased 1.5-fold in treated dogs (P < 0.01) but decreased in untreated dogs (66%, P < 0.001).

Structured PICO

Does ramipril prevent volume-overload hypertrophy in dogs with chronic mitral regurgitation?

Population

18 adult mongrel dogs with induced chronic mitral regurgitation (MR)

Intervention

Ramipril 10 mg orally twice daily for 4 months

Comparator

No ramipril for 4 months after induction of MR

Outcome

Left ventricular (LV) mass measured by cine-magnetic resonance imagingsurrogate

ACE inhibitor therapy with ramipril does not prevent volume-overload cardiac hypertrophy in a canine model of chronic mitral regurgitation, potentially due to compensatory AT1 receptor upregulation.

Cite This Study

Dell'Italia et al. (1997) studied this question.

synapsesocial.com/papers/6a1a20cd8db9fef88db4f507 https://doi.org/10.1152/ajpheart.1997.273.2.h961

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Implication

Ramipril does not prevent hypertrophy in canine volume-overload MR; leaves open ACE inhibitor utility in human chronic mitral regurgitation.

Volume-overload cardiac hypertrophy is unaffected by ACE inhibitor treatment in dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Volume-overload cardiac hypertrophy is unaffected by ACE inhibitor treatment in dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider