November 1, 1997Journal of Cardiovascular Pharmacology

Angiotensin II Subtype-1 Receptor Blockade During the Development of Left Ventricular Hypertrophy in Dogs: Effects on Ventricular and Myocyte Function

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Why the study?

Does irbesartan improve ventricular and myocyte function in a canine model of developing left ventricular hypertrophy?

Population

17 dogs in a pacing-recovery model of developing left ventricular hypertrophy.

Comparison

Irbesartan 30 mg/kg twice daily administered… vs Untreated pacing-recovery group and sham controls.

Design

Preclinical, Randomly assigned

Follow-up

4 weeks (recovery period)

Authors

FSFrancis G. SpinaleHeart Failure & Transplant HHHenry H. HolzgrefeUniversity of Nevada, Reno JWJennifer WalkerPopulation Health Research Institute

Discussion

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Implication

AT1 blockade may modulate experimental LV remodeling; leaves open clinical translation in human hypertrophy.

Structured PICO

Does irbesartan improve ventricular and myocyte function in a canine model of developing left ventricular hypertrophy?

Population

17 dogs in a pacing-recovery model of developing left ventricular hypertrophy (4 weeks of rapid pacing at 216 +/- 2 beats/min followed by a 4-week recovery period).

Intervention

Irbesartan 30 mg/kg twice daily (b.i.d.) administered during the 4-week recovery period.

Comparator

Untreated pacing-recovery group (n=6) and sham controls (n=6).

Outcome

Changes in left ventricular (LV) and myocyte function, including LV mass, LV end-diastolic volume, LV ejection fraction, and myocyte shortening/geometry.surrogate

In a canine model of pacing-induced heart failure, AT1 receptor blockade with irbesartan reduces LV mass and improves some indices of myocyte contractility, suggesting AT1 activation contributes to hypertrophic remodeling.

Cite This Study

Spinale et al. (1997) studied this question.

synapsesocial.com/papers/6a7ca1bf7c7b1859d4ba4abc https://doi.org/10.1097/00005344-199711000-00013

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Angiotensin II Subtype-1 Receptor Blockade During the Development of Left Ventricular Hypertrophy in Dogs: Effects on Ventricular and Myocyte Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II Subtype-1 Receptor Blockade During the Development of Left Ventricular Hypertrophy in Dogs: Effects on Ventricular and Myocyte Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider