July 11, 2000CirculationOpen Access

Reverse Remodeling of Cardiac Myocyte Hypertrophy in Hypertension and Failure by Targeting of the Renin-Angiotensin System

View Full Paper

Ask AI

Bookmark

Why the study?

Does pharmacological targeting of the renin-angiotensin system with AT1 blockers or ACE inhibitors reverse cardiac myocyte hypertrophy in spontaneously hypertensive heart failure rats?

Population

Spontaneously hypertensive heart failure rats, treated between 6 and 10 months of age and between 18 and 22…

Comparison

L-158,809, enalapril, or hydralazine… vs Comparison between L-158,809, enalapril, and…

Design

Preclinical

Follow-up

4 months

Authors

TTTetsutaro TamuraNational Cancer Center Hospital East SSSuleman SaidUniversity of South Dakota JHJennifer L. HarrisUniversity of Connecticut

Discussion

Member takes

Implication

AT1 blockade may warrant study for myocyte reversal in hypertensive HF; extends rat data but leaves open human translation.

Structured PICO

Does pharmacological targeting of the renin-angiotensin system with AT1 blockers or ACE inhibitors reverse cardiac myocyte hypertrophy in spontaneously hypertensive heart failure rats?

Population

Spontaneously hypertensive heart failure rats, treated between 6 and 10 months of age (early treatment) and between 18 and 22 months of age (late treatment)

Intervention

L-158,809 (an AT1 blocker), enalapril (an ACE inhibitor), or hydralazine (a vasodilator) administered for 4 months

Comparator

Comparison between L-158,809, enalapril, and hydralazine

Outcome

Hemodynamics, chamber dimensions, and left ventricular myocyte shape/dimensions (volume and length) after 4 months of treatmentsurrogate

AT1 receptor blockade effectively reverses cardiac myocyte hypertrophy and remodeling in a rat model of hypertensive heart failure, even when initiated late in the disease course.

Limitations

Further work is needed to determine whether similar results can be obtained in humans

Cite This Study

Tamura et al. (2000) studied this question.

synapsesocial.com/papers/6a714b5d2163a0a01bc573cf https://doi.org/10.1161/01.cir.102.2.253

Topics

Heart failure HFrEF treatment Echocardiography

View Full Paper

Ask AI

Bookmark

Reverse Remodeling of Cardiac Myocyte Hypertrophy in Hypertension and Failure by Targeting of the Renin-Angiotensin System

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Reverse Remodeling of Cardiac Myocyte Hypertrophy in Hypertension and Failure by Targeting of the Renin-Angiotensin System

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider