Key result
Right ventricular pacing during isoproterenol stimulation resulted in significantly smaller increases in left ventricular dP/dt and cardiac output compared to sinus rhythm or right atrial pacing (p<0.025).
Why the study?
Does right ventricular pacing compared to right atrial pacing or sinus rhythm alter myocardial performance during inotropic stimulation in a canine model?
Does right ventricular pacing compared to right atrial pacing or sinus rhythm alter myocardial performance during inotropic stimulation in a canine model?
p-value: p=<0.025
Right ventricular pacing impairs the expected increase in myocardial performance and increases myocardial oxygen consumption during inotropic stimulation compared to right atrial pacing or sinus rhythm.
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May blunt inotropic response to catecholamines in animal models; leaves open relevance to human temporary pacing.
Heyndrickx et al. (1985) studied Myocardial performance during inotropic stimulation. Right ventricular pacing with isoproterenol or treadmill exercise vs. Spontaneous rhythm and right atrial pacing was evaluated on Left ventricular dP/dt and cardiac output (p=<0.025). Right ventricular pacing during isoproterenol stimulation resulted in significantly smaller increases in left ventricular dP/dt and cardiac output compared to sinus rhythm or right atrial pacing (p<0.025).
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