Population
67 open-chest dogs under pentobarbital anesthesia
Comparison
Isoproterenol stimulation and lowered oxygen… vs Baseline state, mechanical maintenance of high…
Design
Preclinical
Authors
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May indicate transient myocardial depression risk with isoproterenol; leaves open human relevance and clinical implications.
Isoproterenol-induced increases in cardiac rate and force can lead to a transient depression of myocardial function due to sharply decreased oxygen delivery and coronary perfusion pressure.
Daniell et al. (1967) studied this question.
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