Why the study?
Does isoproterenol or propranolol alter high-energy phosphate levels in ischemic myocardium in dogs?
Population
Dog model of ischemic myocardium with two coronary branches on the same heart simultaneously perfused at a…
Comparison
Isoproterenol or propranolol infusion vs 0.9% NaCl infusion in a separate coronary branch…
Design
Preclinical
Follow-up
1 hour
Authors
Loading...
Hypothesis-generating for beta-blockade energetics in ischemia; no basis to alter clinical practice.
Does isoproterenol or propranolol alter high-energy phosphate levels in ischemic myocardium in dogs?
In a canine model of myocardial ischemia, propranolol preserved high-energy phosphate concentrations, suggesting it reduces energy utilization, whereas isoproterenol did not accelerate it.
Goodlett et al. (1980) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: