Why the study?
Does inotropic alteration with propranolol or isoproterenol affect the severity of myocardial ischemia after acute coronary occlusion in experimental dogs?
Population
10 experimental dogs undergoing repetitive occlusions of a main branch of the left anterior descending…
Comparison
Propranolol in 5 dogs; Isoproterenol in 5 dogs vs Simple control occlusion (baseline state)
Design
Preclinical
Follow-up
15 minutes
Authors
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Hypothesis-generating for beta-adrenergic modulation of ischemic injury in occlusion models; prospective human studies needed before clinical adoption.
Does inotropic alteration with propranolol or isoproterenol affect the severity of myocardial ischemia after acute coronary occlusion in experimental dogs?
In a canine model of acute coronary occlusion, decreasing myocardial contractility with propranolol reduces ischemic injury, while increasing contractility with isoproterenol exacerbates ischemia.
Watanabe et al. (1972) studied this question.
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