Reducing Myocardial Injury by Minimizing Imbalance between Oxygen Supply and Demand
Why the study?
Do hemodynamic and pharmacologic factors influence the extent and severity of myocardial necrosis produced by coronary occlusion in dogs?
Population
67 dogs undergoing experimental coronary occlusion of a branch of the left anterior descending coronary artery
Comparison
Pharmacologic agents and hemodynamic alterations… vs Control occlusion without intervention
Design
Preclinical
Follow-up
24 hours
Authors
Discussion
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Member takes
Implication
Hemodynamic and pharmacologic factors may modify ischemic injury in canine models; leaves open translation to human infarction.
Structured PICO
Do hemodynamic and pharmacologic factors influence the extent and severity of myocardial necrosis produced by coronary occlusion in dogs?
P
Population
67 dogs (48 in initial experiments, 19 in additional experiments) undergoing experimental coronary occlusion of a branch of the left anterior descending coronary artery
I
Intervention
Pharmacologic agents (isoproterenol, ouabain, glucagon, bretylium, propranolol, methoxamine) and hemodynamic alterations (tachycardia, hemorrhage) administered prior to or up to 3 hours after coronary occlusion
C
Comparator
Control occlusion without intervention
O
Outcome
Severity and extent of myocardial ischemic injury, measured by average S-T segment elevation and myocardial creatine phosphokinase (CPK) activitysurrogate
Hemodynamic status and neurohumoral background at the time of and up to 3 hours after coronary occlusion can significantly alter the extent of myocardial ischemic injury and necrosis.
Cite This Study
Braunwald et al. (2007) studied this question.