Reduction by Hyaluronidase of Myocardial Necrosis following Coronary Artery Occlusion
Why the study?
Does hyaluronidase reduce myocardial necrosis following acute coronary occlusion in a canine model?
Population
29 dogs with experimentally produced myocardial infarcts via occlusion of the left anterior descending…
Comparison
Hyaluronidase (225 u/kg) vs Control (no hyaluronidase)
Design
Preclinical
Follow-up
24 hours
Authors
Discussion
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Implication
Hyaluronidase limits early necrosis in canine occlusion; hypothesis-generating and requires clinical trials before human application.
Structured PICO
Does hyaluronidase reduce myocardial necrosis following acute coronary occlusion in a canine model?
P
Population
29 dogs with experimentally produced myocardial infarcts via occlusion of the left anterior descending coronary artery
I
Intervention
Hyaluronidase (225 u/kg)
C
Comparator
Control (no hyaluronidase)
O
Outcome
Myocardial necrosis assessed by creatine phosphokinase (CPK) activity, histologic changes, and glycogen content at 24 hourssurrogate
Hyaluronidase administration diminishes myocardial necrosis following acute coronary occlusion in a canine model.
Cite This Study
Maroko et al. (1972) studied this question.