Structural Heart
Valvular heart disease
Aortic stenosis, mitral regurgitation, and valve management
Emerging pathwayAlso known as: VHD, aortic stenosis, mitral regurgitation
3,062
Clinical questions
166
Evidence-backed
67
Claims analyzed
Structural Heart
Aortic stenosis, mitral regurgitation, and valve management
Synthesized from 166 evidence-backed clinical questions linked to this topic — 4 supporting the intervention, 6 against the intervention, 1 still contested.
Does female sex vs placebo improve outcomes in systolic murmurs?
Low Certainty− Favors harmfemale sex vs placebo
20 studies (247,754 patients) provide low-certainty evidence against benefit of female sex for the outcome in systolic murmurs.
Does remifentanil vs placebo improve outcomes in Aortic stenosis, severe?
Low Certainty− Favors harmremifentanil vs placebo
7 studies (10,812 patients) provide low-certainty evidence against benefit of remifentanil for the outcome in Aortic stenosis, severe.
Does female sex vs placebo improve outcomes in Heart valve disease?
Low Certainty− Favors harmfemale sex vs placebo
2 studies (5,559 patients) provide low-certainty evidence against benefit of female sex for the outcome in Heart valve disease.
Does dapagliflozin vs placebo improve outcomes in Functional mitral regurgitation?
Low Certainty+ Favors benefitdapagliflozin vs placebo · Myocardial Infarction Hospitalization
26 studies (3,320 patients) provide low-certainty evidence for benefit of dapagliflozin for Myocardial Infarction Hospitalization in Functional mitral regurgitation.
Does propofol vs remifentanil improve outcomes in severe symptomatic aortic stenosis?
Low Certainty− Favors harmpropofol vs remifentanil
5 studies (559 patients) provide low-certainty evidence against benefit of propofol for the outcome in severe symptomatic aortic stenosis.
Does balloon aortic valvuloplasty vs placebo improve outcomes in Aortic stenosis, severe?
Low Certainty+ Favors benefitballoon aortic valvuloplasty vs placebo
2 studies (389 patients) provide low-certainty evidence for benefit of balloon aortic valvuloplasty for the outcome in Aortic stenosis, severe.
Emerging evidence with 67 primary claims
Specific, answerable questions in this area — each with its own synthesized evidence and consensus. Open one to see the forest plot, source trials, and how the consensus has changed over time.
Does dapagliflozin vs placebo improve outcomes in Functional mitral regurgitation?
Low Certainty+ Favors benefitdapagliflozin vs placebo · Myocardial Infarction Hospitalization
Does dapagliflozin vs placebo improve Myocardial Infarction Hospitalization in Functional mitral regurgitation?
Low Certainty+ Favors benefitdapagliflozin vs placebo · Myocardial Infarction Hospitalization
Comparison of Different Decellularization Procedures of Porcine Heart Valves
The International Journal of Artificial Organs — Kasimir M — May 2003
A WeChat platform program (WCPP) for full-process management of patients with cardiac valve interventional surgery based on psycho-cardiology: protocol of a mixed-method study
Trials — Xu Y — Oct 2024
The Pulmonary Capillary Bed in Various Forms of Pulmonary Hypertension
Circulation — McCredie R — Jun 1966
Mineral metabolism disturbances are associated with the presence and severity of calcific aortic valve disease
Journal of Zhejiang University SCIENCE B — Yang Z — May 2015
Treating cardiovascular complications of radiotherapy: a role for new pharmacotherapies
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Valvular heart disease (also known as VHD, aortic stenosis, mitral regurgitation). Aortic stenosis, mitral regurgitation, and valve management
Synapse tracks 3 specific clinical questions in Valvular heart disease, each synthesized independently from its own trial evidence. They include: "Does dapagliflozin vs placebo improve outcomes in Functional mitral regurgitation?"; "Does dapagliflozin vs placebo improve Myocardial Infarction Hospitalization in Functional mitral regurgitation?"; "Does sodium ferric gluconate complex vs placebo improve outcomes in Aortic stenosis, severe?".
As of 2026-08-15, the scientific consensus on Valvular heart disease is emerging. Emerging evidence with 67 primary claims Based on 67 analyzed claims across Synapse's enriched corpus, the evidence shows.
This evidence brief synthesizes Synapse's enriched cardiology corpus; cite as synapsesocial.com/topics/valvular-heart-disease.
Deterministic synthesis from Synapse's enriched corpus — 114 words. No AI-generated novel content; every figure is sourced from the underlying paper, guideline, or trial record linked on this page.
Explore every Valvular heart disease paper on Synapse with AI-enriched clinical evidence, PICO analysis, and methodology classification.
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Expert Opinion on Pharmacotherapy — Donis N — Mar 2018