Tricuspid regurgitation

Overview

Unverified · drafted by AI from the sources cited below

Definition

Tricuspid regurgitation is characterized by the backflow of blood from the right ventricle into the right atrium due to imperfect closure of the tricuspid valve.1

Treatment

Transcatheter edge-to-edge repair and transcatheter tricuspid valve replacement (TTVR) are therapeutic options for patients with severe tricuspid regurgitation.123456 The TRILUMINATE trial (n = 85) demonstrated that TR was reduced to moderate or less in 71% of subjects at 1 year, compared with 8% at baseline.1 The TRISCEND study (n = 176) evaluated TTVR and showed significant improvements in functional status, with New York Heart Association class I or II achieved in 93.3% of patients.3 A study of patients with large tricuspid annuli undergoing TTVR with the 55-70 mm LuX-Valve Plus system found an intraprocedural success rate of 95.6%.6 In an adult with Ebstein's anomaly, totally endoscopic three-dimensional tricuspid valve repair was performed, involving tricuspid annuloplasty with a semi-rigid partial ring and edge-to-edge valvuloplasty.7

New research on Tricuspid regurgitation

Late Discordance Between Right Ventricular Fractional Area Change and Free‐Wall Longitudinal Strain After Cardiac Surgery Including Tricuspid Annuloplasty

Echocardiography — Nakai T — Nov 2026

Admission Albumin-Corrected Anion Gap and Subsequent Tricuspid Regurgitation Velocity Elevation After COPD Exacerbation

Journal of Visualized Experiments — Zhao Z — Oct 2026

VExUS Score and Hepatorenal Congestion Improvements After Transcatheter Tricuspid Intervention

JACC: Cardiovascular Interventions — Pérez A — Aug 2026

Outcomes of patients with large anatomies undergoing transcatheter tricuspid valve replacement with the LuX-Valve Plus system

Journal clubs discussing Tricuspid regurgitation

Recent sessions

Tri.Fr: The Heart of the Matter

OPCI Journal Club — Fri, Aug 7, 12:00 PM EDT

Sessions from public communities on Synapse. RSVP to join the live discussion.

Journal Club takes on Tricuspid regurgitation

“Tri.Fr demonstrates durable 30-month reductions in heart failure hospitalizations for isolated tricuspid regurgitation without establishing a clear survival benefit.”
Tri.Fr: The Heart of the MatterOPCI Journal Club · Aug 11, 2026

Key papers

Transcatheter Edge-to-Edge Repair for Treatment of Tricuspid Regurgitation

Journal of the American College of Cardiology — Lurz P

465 citations · 2021 · among the most cited on Tricuspid regurgitation

Right Ventricular-Pulmonary Arterial Coupling and Afterload Reserve in Patients Undergoing Transcatheter Tricuspid Valve Repair

Journal of the American College of Cardiology — Brener M

304 citations · 2022 · among the most cited on Tricuspid regurgitation

Transfemoral tricuspid valve replacement and one-year outcomes: the TRISCEND study

European Heart Journal — Kodali S

258 citations · 2023 · among the most cited on Tricuspid regurgitation

Feasibility Study of the Transcatheter Valve Repair System for Severe Tricuspid Regurgitation

Journal of the American College of Cardiology — Kodali S

237 citations · 2021 · among the most cited on Tricuspid regurgitation

How this page is built

A clinical question appears here only when its condition matches this topic, an outcome and a comparator were extracted from the studies, at least two studies and a patient count are on file, and the certainty is low or higher.

Supports benefit, no benefit shown, and mixed describe the direction of the measured effect. No benefit shown means the evidence does not support a benefit. It is not a finding of harm. Too little evidence means the question did not clear that bar.

Study count, RCT count, and patient count are separate. The patient total adds only studies that are linked into a study family and whose sample size is not flagged as implausible. A reversal is listed only when at least one randomized trial sits on each side of the change.

The overview is drafted from the guideline recommendations, trials, papers, and questions on this page, and every sentence has to cite one of them. It stays unverified until an NPI-verified clinician or a Synapse admin approves it. Approving records that person's name.