May 17, 2026Journal of the American College of Cardiology
Transcatheter Edge-to-Edge Repair for Treatment of Tricuspid Regurgitation
Key result
TriClip repair reduces TR to moderate or less in 71% of patients at one year.
- P<0.0001
- n=85
Why the study?
Tricuspid regurgitation is associated with increasing mortality as severity increases, and transcatheter therapies may offer an alternative to surgery in this high-risk population.
Does transcatheter tricuspid valve repair using the TriClip device improve outcomes in patients with moderate or greater tricuspid regurgitation?
Population
85 patients with moderate or greater TR
Comparison
Transcatheter tricuspid valve repair with the TriClip device (single-arm)
Design
International, prospective, single arm, multicenter study
Follow-up
1 year
Authors
Discussion
Loading...
Member takes
Implication
Supports TR reduction with TriClip in high-risk patients; leaves open outcome benefits and need for RCTs before practice change.
Key Points
- To evaluate the 1-year safety, repair durability, and clinical outcomes of the TriClip transcatheter tricuspid valve repair system in high-risk patients with tricuspid regurgitation.
- International, prospective, single-arm, multicenter interventional trial (TRILUMINATE; NCT03227757) evaluating the TriClip system in N=85 patients with moderate or greater tricuspid regurgitation.
- Patients underwent core laboratory echocardiographic evaluations and functional assessments across a 1-year follow-up period.
- Tricuspid regurgitation was reduced to moderate or less in 71% of subjects at 1 year compared with 8% at baseline (p < 0.0001).
- NYHA functional class I/II increased from 31% to 83% (p < 0.0001), 6-minute walk distance improved from 272.3 ± 15.6 to 303.2 ± 15.6 meters (p = 0.0023), and KCCQ score improved by 20 ± 2.61 points (p < 0.0001).
- Significant reverse right ventricular remodeling occurred, while the overall major adverse event rate and all-cause mortality were each 7.1% at 1 year.
Study Design
Type
Cohort (n=85)
Multicenter
Yes
Structured PICO
Does transcatheter tricuspid valve repair using the TriClip device improve outcomes in patients with moderate or greater tricuspid regurgitation?
P
Population
n=85 patients with moderate or greater tricuspid regurgitation (TR) at high surgical risk, international cohort.
I
Intervention
Transcatheter tricuspid valve repair using the TriClip device
O
Outcome
1-year outcomes including repair durability, clinical benefit, and safety
Main Result
Absolute Event Rate: 71% vs 8%
p-value: p=<0.0001
Transcatheter tricuspid valve repair with the TriClip device safely and effectively reduces tricuspid regurgitation and improves clinical symptoms at 1 year in high-risk patients.
Cite This Study
Lurz et al. (2021) conducted a cohort in Moderate or greater tricuspid regurgitation (n=85). TriClip transcatheter tricuspid valve repair system was evaluated on Reduction of tricuspid regurgitation to moderate or less (p=<0.0001). Transcatheter tricuspid valve repair using the TriClip system reduced tricuspid regurgitation to moderate or less in 71% of patients at 1 year compared to 8% at baseline (p<0.0001).