David R. Holmes

In patients with type 2 diabetes and stable ischemic heart disease, a mid/high SYNTAX score (≥23) predicts higher rates of major cardiovascular events and identifies patients who derive significant benefit from CABG revascularization over medical therapy.

Hypothesis-generating for myocardial bridging in HCM; prospective studies needed before clinical adoption.

May warrant closer ECG surveillance in myotonic dystrophy; leaves open prospective validation of sudden-death risk stratification.

Antiplatelet therapies retain their established preventive role; leaves open refinement via genomics and predictive factors in future studies.

Left atrial appendage closure is an effective strategy for stroke prevention in AF, though challenges remain regarding patient and device selection, as well as management of periprocedural complications.

Epicardial and endocardial LAA occlusion devices exert substantially different physiological, hemodynamic, and neurohormonal effects, suggesting that the method of LAA exclusion impacts systemic homeostasis.

Randomized double-blind trial demonstrates reduced repeat revascularization with sirolimus-eluting stents in coronary disease, indicating long-term efficacy without increased safety risks.

Clinical cohort study reveals increased mortality after peri-procedural myocardial infarction in coronary revascularization patients, highlighting the need to minimize procedural injury.

EECP is a valuable treatment option for patients with refractory angina, with potential mechanisms of benefit including improved endothelial function, coronary collateralization, and enhanced ventricular function.

Clinical review demonstrates therapeutic efficacy of catheter-based interventions in coronary artery disease, highlighting techniques to restore myocardial perfusion.

This review highlights novel nonthrombogenic functions of the left atrial appendage that may have important therapeutic implications beyond stroke prevention in atrial fibrillation.

Postmortem study demonstrates sex-divergent microglial morphology at high Alzheimer's neuropathology in human brains, suggesting sex-specific immune reactivity across disease progression.

Clinical review highlights diagnostic pathways and interventional management in pulmonary vein stenosis, indicating multimodal assessment and catheter-based therapies optimize clinical outcomes.

TAVR may lower HF hospitalizations and costs in severe AS; leaves open net resource impact across broader real-world populations.

May warrant enhanced perioperative arrhythmia monitoring after Ebstein repair; leaves open prospective evaluation of preventive strategies.