Key result
LAA possesses novel nonthrombogenic functions beyond cardioembolism with important therapeutic implications.
Why the study?
Research has largely focused on the thrombogenic role of the LAA in stroke prevention, but recent studies highlight novel nonthrombogenic functions that may have therapeutic implications.
This review highlights novel nonthrombogenic functions of the left atrial appendage that may have important therapeutic implications beyond stroke prevention in atrial fibrillation.
The atrial appendage (LAA) is a well-established source of cardioembolism in patients with atrial fibrillation. Therefore, research involving the LAA has largely focused on its thrombogenic attribute and the utility of its exclusion in stroke prevention. However, recent studies have highlighted several novel functions of the LAA that may have important therapeutic implications. In this paper, we provide a concise overview of the LAA anatomy and summarize the emerging data on its nonthrombogenic roles.
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Alkhouli et al. (2023) conducted a review in Atrial fibrillation. Left Atrial Appendage was evaluated. The left atrial appendage possesses several novel nonthrombogenic functions beyond its well-established role in cardioembolism, which may have important therapeutic implications.
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