Higher 2D-echocardiographic right ventricular end-diastolic volume index was associated with increased 1-year mortality or heart failure rehospitalization (HR 1.05 per 10 mL/m2; 95% CI 1.01-1.10).
Cohort (n=113)
No
Does 2D-echocardiographic estimation of right ventricular volumes predict outcomes in patients undergoing transcatheter tricuspid interventions?
Right ventricular volumes derived from a simple 2D echocardiographic model are associated with clinical outcomes in patients undergoing transcatheter tricuspid interventions.
Hazard Ratio: 1.05 (95% CI 1.01–1.1)
p-value: p=0.03
Abstract Aims To determine whether a simplified, previously proposed two‐dimensional (2D) approach to RV volume assessment can provide adjunctive prognostic information in patients undergoing Transcatheter Tricuspid Valve Interventions (TTVI). Methods and Results In this prospective single‐center study, 113 patients undergoing TTVI were included (T‐TEER; n = 91, heterotopic caval valve implantation; n = 17, and orthotopic transcatheter tricuspid valve replacement; n = 5). RV end‐diastolic and end‐systolic volumes were calculated using a previously described 2D‐based geometric model. The primary endpoint was a composite of all‐cause mortality or rehospitalization for acute decompensated heart failure at 1 year. The primary endpoint occurred in 47 patients (41.6%). In univariable Cox regression analysis, both RVEDVi (HR 1.05 per 10 mL/m 2 , 95% CI 1.01–1.10, p = 0.03) and RVESVi (HR 1.13 per 10 mL/m 2 , 95% CI 1.01–1.25, p = 0.03) were associated with adverse outcome. Receiver operating characteristic analysis identified cut‐off values of 90 mL/m 2 for RVEDVi and 35 mL/m 2 for RVESVi. Patients above these thresholds (diastolic, systolic, or both) showed significantly reduced event‐free survival (log‐rank p < 0.01). In a multivariable Cox regression analysis, RV dilatation showed a trend toward worse outcomes (HR 2.09, 95% CI 0.91–4.80, p = 0.08), whereas the TriScore remained independently associated with outcome (HR 1.30, 95% CI 1.10–1.53, p < 0.01). Conclusion RV volumes derived from a simple 2D echocardiographic model are associated with clinical outcomes and may provide additional information for the assessment of patients undergoing TTVI.
Alachkar et al. (Wed,) conducted a cohort in Transcatheter Tricuspid Valve Interventions (TTVI) (n=113). 2D-echocardiographic estimation of right ventricular volumes was evaluated on Composite of all-cause mortality or rehospitalization for acute decompensated heart failure at 1 year (HR 1.05, 95% CI 1.01-1.10, p=0.03). Higher 2D-echocardiographic right ventricular end-diastolic volume index was associated with increased 1-year mortality or heart failure rehospitalization (HR 1.05 per 10 mL/m2; 95% CI 1.01-1.10).