What is the clinical evidence from this study?

Study design: Other. Population: Congestive heart failure (n=6). Intervention: Rapid pacing-induced congestive heart failure vs. Baseline. Primary outcome: Peak early diastolic filling rate (p=< .05).

What does this research mean for the field?

In a canine model of pacing-induced congestive heart failure, peak early filling rate initially decreases due to slowed left ventricular relaxation but progressively increases over 4 weeks as left atrial pressure rises, while increasing left ventricular stiffness shortens the early filling deceleration time. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to understand how left ventricular filling patterns change during the development of congestive heart failure (CHF).

July 9, 2026CirculationOpen Access

Mechanism of altered patterns of left ventricular filling during the development of congestive heart failure.

Q: What are the key findings of this study?

In a canine model of pacing-induced congestive heart failure, peak early filling rate initially decreased but progressively increased from 108 to 168 mL/s by 4 weeks (P < .05).

Q: What does this research mean for the field?

In a canine model of pacing-induced congestive heart failure, peak early filling rate initially decreases due to slowed left ventricular relaxation but progressively increases over 4 weeks as left atrial pressure rises, while increasing left ventricular stiffness shortens the early filling deceleration time. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

This research aims to understand how left ventricular filling patterns change during the development of congestive heart failure (CHF).

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Key result

Pacing-induced heart failure in canines progressively increases peak early diastolic filling rate by ~56%.

P<.05
n=6

Why the study?

The mechanism underlying altered left ventricular filling patterns during the development of congestive heart failure was not fully understood.

Population

Six conscious dogs instrumented to measure LV and LA pressures and LV volume

Comparison

Serial measurements during CHF induced by rapid pacing vs baseline

Design

Animal physiological study

Follow-up

4 weeks

Authors

MOM OhnoShowa University CCC P ChengNational Tainan Institute of Nursing WLWilliam C. LittleInterventional Cardiology

Discussion

Member takes

Implication

Dynamic diastolic filling in experimental HF warrants clinical caution; leaves open validation of stiffness markers in human cohorts.

Key Points

This research aims to understand how left ventricular filling patterns change during the development of congestive heart failure (CHF).
Instrumented six conscious dogs to measure left ventricular (LV) and left atrial (LA) pressures and LV volume during induced CHF.
Measured diastolic filling dynamics over four weeks during pacing and normal sinus rhythm.
Analyzed correlations between early filling rates and pressure gradients.
The peak early diastolic filling rate decreased from 108 to 88 mL/s (P < .05) initially due to decreased LA-LV pressure gradient.
After one week, the peak filling rate returned to control and increased to 168 mL/s by week four (P < .05).
The early filling deceleration time decreased over four weeks, reflecting increased LV stiffness (r = .94, P < .01).

Structured PICO

Population

6 conscious dogs instrumented to measure LV and LA pressures and LV volume as CHF was induced by rapid pacing over 4 weeks.

Exposure

Induction of congestive heart failure (CHF) by rapid pacing

Comparator

Baseline (control) state before pacing

Outcome

Diastolic filling dynamics (peak early diastolic filling rate, LA-LV pressure gradient, LV relaxation rate, deceleration time) measured seriallysurrogate

Main Result

Absolute Event Rate: 168% vs 108%

p-value: p=< .05

In a canine model of pacing-induced heart failure, early filling deceleration time reflects LV stiffness, with filling patterns changing dynamically as LA pressure overcomes impaired LV relaxation.

Cite This Study

Ohno et al. (1994) studied Congestive heart failure (n=6). Rapid pacing-induced congestive heart failure vs. Baseline was evaluated on Peak early diastolic filling rate (p=< .05). In a canine model of pacing-induced congestive heart failure, peak early filling rate initially decreased but progressively increased from 108 to 168 mL/s by 4 weeks (P < .05).

synapsesocial.com/papers/6a4f13342dbc4344f5ff7ac5 https://doi.org/10.1161/01.cir.89.5.2241

Topics

Heart failure HFrEF treatment

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Mechanism of altered patterns of left ventricular filling during the development of congestive heart failure.

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Topics

Mechanism of altered patterns of left ventricular filling during the development of congestive heart failure.

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider