Key result
Exercise in dogs with pacing-induced CHF increased maximum LV filling rate (141 vs 200 ml/sec, p<0.05) driven by increased mean LA pressure rather than decreased early diastolic LV pressure.
Why the study?
Does congestive heart failure alter the mechanism of exercise-induced augmentation of mitral valve flow in a canine model?
Population
18 conscious dogs instrumented to measure micromanometer LV and LA pressures and determine LV volume from…
Comparison
Exercise vs Resting state before and after CHF
Design
Preclinical
Authors
Loading...
Exercise augments LV filling via LA pressure in canine CHF; leaves open human diastolic mechanisms and exercise intolerance.
Does congestive heart failure alter the mechanism of exercise-induced augmentation of mitral valve flow in a canine model?
Absolute Event Rate: 200% vs 141%
p-value: p=<0.05
In a canine model of CHF, exercise-induced augmentation of mitral valve flow is driven by an increase in LA pressure rather than a fall in early diastolic LV pressure, which may contribute to exercise intolerance.
Cheng et al. (1993) studied Congestive heart failure (n=18). Exercise vs. Rest was evaluated on Maximum rate of LV filling (dV/dtmax) after CHF (p=<0.05). Exercise in dogs with pacing-induced CHF increased maximum LV filling rate (141 vs 200 ml/sec, p<0.05) driven by increased mean LA pressure rather than decreased early diastolic LV pressure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: