Key result
Exercise in conscious dogs increased the maximum rate of change of LV volume from 185 to 282 ml/sec (p<0.01) and decreased minimum LV pressure from 3.3 to -2.8 mm Hg (p<0.05).
Absolute Event Rate: 282% vs 185%
p-value: p=<0.01
During exercise, sympathetic stimulation and tachycardia produce a downward shift of the early diastolic portion of the LV pressure-volume loop, augmenting the rate of LV filling.
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Supports enhanced LV filling during exercise in dogs; leaves open human translation.
Cheng et al. (1992) studied Normal physiology (n=13). Exercise (treadmill running) vs. Rest was evaluated on Maximum rate of change of left ventricular volume (dV/dtmax) (p=<0.01). Exercise in conscious dogs increased the maximum rate of change of LV volume from 185 to 282 ml/sec (p<0.01) and decreased minimum LV pressure from 3.3 to -2.8 mm Hg (p<0.05).
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