Key result
Creation of significant mitral regurgitation in conscious dogs increased the filling fraction during the first 40% of diastolic time from 51% at control to 76% at 4 weeks (p<0.001).
Why the study?
Does the creation of significant mitral regurgitation alter early diastolic filling dynamics in conscious dogs?
Population
5 conscious dogs instrumented with a micromanometer and sonomicrometers
Comparison
Creation of significant mitral regurgitation vs Control state
Design
Preclinical
Follow-up
up to 4 weeks
Authors
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May accelerate early LV filling in MR volume overload; animal model leaves open human translation.
Does the creation of significant mitral regurgitation alter early diastolic filling dynamics in conscious dogs?
Absolute Event Rate: 76% vs 51%
p-value: p=<0.001
In a canine model of mitral regurgitation, the left ventricle adapts to volume overload by accommodating a higher percentage of total stroke volume during early diastole, associated with reduced chamber elastance and eccentricity.
Katayama et al. (1988) studied Mitral regurgitation (n=5). Creation of significant mitral regurgitation vs. Control state (before creation) was evaluated on Filling fraction during the first 40% of diastolic time (p=<0.001). Creation of significant mitral regurgitation in conscious dogs increased the filling fraction during the first 40% of diastolic time from 51% at control to 76% at 4 weeks (p<0.001).
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