Key result
Increasing preload or inotropy raised stroke volume in proportion to the diastolic atrio-ventricular pressure time product (r > 0.9) through different mechanisms.
Population
Anesthetized, open-chest dogs with intact or mechanically constricted mitral ostium
Design
Preclinical
Authors
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Should not change preload or inotrope use; leaves open validation of AV pressure time product in human HF.
Effect estimate: r > 0.9
The atrio-ventricular pressure difference driving left ventricular filling is generated through different mechanisms when raising preload versus inotropy, depending on whether heart rate changes.
THORVALDSON et al. (1983) studied this question. Increasing preload (blood volume expansion) or infusing isoproterenol was evaluated on Stroke volume in proportion to the pressure time product (PTP) (r > 0.9). Increasing preload or inotropy raised stroke volume in proportion to the diastolic atrio-ventricular pressure time product (r > 0.9) through different mechanisms.
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