Why the study?
How do changes in inotropy and preload affect the relationship between stroke volume and heart rate during right atrial pacing in open-chest dogs?
Population
Open-chest dogs
Comparison
Right atrial pacing at heart rates exceeding 150… vs Control inotropy and before blood volume expansion
Design
Preclinical
Authors
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Separates preload from inotropic effects on SV-HR in dogs; leaves open translation to human pacing or HF.
How do changes in inotropy and preload affect the relationship between stroke volume and heart rate during right atrial pacing in open-chest dogs?
In an open-chest dog model, the effects of preload and inotropy on stroke volume are separable during right atrial pacing, with stroke volume being independent of heart rate at constant preload and adrenergic stimulation.
Ilebekk et al. (1979) studied this question.
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