Why the study?
Does increasing heart rate via right atrial pacing affect left ventricular performance and myocardial contractility in conscious dogs?
Population
12 conscious dogs
Comparison
Right atrial pacing to increase heart rate… vs Baseline heart rate / steady-state
Design
Preclinical
Authors
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Contractility remains rate-independent in conscious dogs; leaves open translation to human pacing or ventricular performance.
Does increasing heart rate via right atrial pacing affect left ventricular performance and myocardial contractility in conscious dogs?
In conscious dogs, myocardial contractility (LV dP/dt max) remains unaffected by changes in heart rate within the physiologic range (90-190 beats/min), despite reductions in stroke volume and end-diastolic volume.
Noble et al. (1969) studied this question.
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